Anorgasmia after starting bupropion

Sexual / Libido

I’m 29F and before starting bupropion I had an insanely low sex drive (like maybe a few times a year) but I was able to orgasm easily. Plus, my partner knows my body well and has always been able to make me cum super hard. Like seeing stars or whatever (I promise this is relevant).

Since starting bupropion, my libido has skyrocketed. I can’t get enough. But I can’t orgasm anymore and it’s awful, especially since I had literally no problems before. I started 150mg XL in early March and my psychiatrist bumped up my dose to 300mg on April 20th. I’ve had the issue since at least Easter, so it was definitely on the lower dose. It’s like being on a roller coaster and you reach the very top and then slide back down. My body reacts like it should, but I just don’t feel the actual release or pleasure really. They just suck now.

I’ve read about people having this issue, but it seems like a lot of times they couldn’t cum easily before either. Or they lost their libido or both. Has anyone ever had it where orgasm was great before and then went away after starting the medicine? And did it hopefully get better? I really really want to stay on this because it helps my mood and some of my ADHD symptoms and honestly I like having a high libido. It’s a great fit for me in ever way minus orgasming :(

Posted May 12, 2026, 6:22 AM UTC

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