Same research direction but in different application

Hi, i am hoping this reaches profs or senior-level grad students here.

I wanted to ask if its a good idea to reach out a professor (in CS/AI) for potential fit and/or phd supervision, if their research direction/statement is what I would like to pursue but they havenot pursued (themselves or via any other of their current student) it for the application I am intrested in ?

For example, I have shortlisted a prof/lab, their main area of work is causal discovery and ML but most of their work is done earth/atmoshpere related whereas I am intresred in pursuin the same direction but for healthcare/medical ai. Thanks.