7oh IS NOT DANGEROUS

Repost

\##This is a post from a user in this subreddit. I feel it needs a repost.

From another post I made which pertains here as well:

It makes me so mad when people in power spread so much misinformation. The FDA Commissioner is saying "7oh is 13x more potent than morph!ne". Total misinformation..it is 13x stronger at BINDING TO THE RECEPTOR!!!!

13x stronger at binding to the receptor only raises questions about duration of action, spacing of doses, how long side effects linger, and also about how these agents interact with your receptors can affect other processes.

This is from user u/glowant22.

Here is a government clinical study showing that they can not find a lethal dose of 7oh

From the trial:

"Lethality.

We wanted to compare IV to oral lethality for the two alkaloids of Kratom, so we also determined an approximate oral LD50 value for mitragynine using the following doses: 500, 250, 125, and 62.5 mg/kg .

We attempted to determine an oral LD50 value for 7-hydroxymitragynine; however, none of the mice expired at any of the doses (50, 25, 12.5, and 6.25 mg/kg;)."

Then he has the audacity to say it causes "FATAL RESPIRATORY DEPRESSION"! THIS MAKES ME SO MAD! IT DOESN'T HAVE THE ABILITY TO CAUSE FATAL RESPIRATORY DEPRESSION! It is just a partial opioid agonist, that has a ceiling effect!

Yes! 7-hydroxymitragynine (7-OH) is a potent partial agonist at the mu-opioid receptor. 

CEILING EFFECT OF 7OH------

7-Hydroxymitragynine (7-OH), a potent active metabolite of mitragynine found in kratom, functions as a partial agonist at the -opioid receptor (MOR). This partial agonism creates a "ceiling effect," a pharmacological phenomenon where, beyond a certain dosage, increases in dose do not produce a corresponding increase in effect, specifically regarding respiratory depression.

Key Aspects of the 7-OH Ceiling Effect:

Respiratory Safety Cap:

Because 7-OH is a partial agonist, it triggers significant pain relief but typically does not drive maximum -opioid receptor activation, which caps its respiratory depression potential compared to full agonists like M0RPH1N3.

Biased Agonism:

7-OH preferentially activates G-protein signaling while weakly triggering the -arrestin-2 pathway. The -arrestin-2 pathway is strongly linked to classic opioid side effects, including respiratory depression, constipation, and tolerance.

Distinction from Mitragynine:

While the parent compound (mitragynine) has a pronounced, built-in ceiling effect due to its slow metabolic conversion to 7-OH (metabolic saturation), 7-OH itself can exhibit a more linear dose-dependent effect, particularly at very high doses, according to some studies.

Similarity to Buprenorphine:

Similar to the opioid addiction treatment buprenorphine, 7-OH's ceiling effect contributes to a potentially safer profile than traditional full-agonist opioids

Another article had the audacity to put this nonsense out there.

"Serious health outcomes linked to kratom have also surged. Hospitalizations involving only kratom rose more than 1,150% over the decade, climbing from 43 cases in 2015 to 538 in 2025.

When kratom was combined with other substances, such as illicitdrugs or antidepressants, hospitalizations increased nearly 1,300%, from 40 to 549.

During the study period, 233 deaths were associated with kratom use. Of those, 184 involved multiple substances."

So out of the millions of people who use Kratom, around 500 have been hospitalized when combined with other substances.....(not much considering 1 person dies from alcohol related causes every 39 minutes)... And out of the 233 deaths, 184 involved multiple substances....not much in the grand scheme of things...

LETS TALK ABOUT HOSPITALIZATIONS AND DEATHS FROM AlC0H0L(ETOH), WHICH IS LEGAL and found on every corner.. CUT IT OUT WITH THE SENSATIONALIZED NONSENSE.

ETOH-related deaths in the US remain high, with over 140,000 Americans dying annually from AlC0H0L(ETOH)related causes, averaging nearly 390 per day.

 Although fatalities fell from a 2021 peak of 54,258, 2024 data shows deaths remained 50% higher than a decade ago. ETOH-related hospitalizations have stabilized, but those with primary complications (e.g., liver disease) increased through 2022.

Key 2025/2026 AlC0H0L(ETOH)-Related Data Points Death Rates:

ETOH-related deaths dropped in 2023 and 2024 compared to the 2021 peak, yet remained roughly 20% higher than pre-pandemic levels (2019). 

Cancer Deaths:

ETOH contributes to approximately 20,000 cancer deaths in the US annually.

Hospitalization Trends:

While overall ETOH-related hospitalizations stabilized, cases with a primary diagnosis of ETOH-related medical complications increased from 70 to 83 per 100,000 between 2016 and 2022.

People need to fight this misinformation with true information.  So these lobbyists are literally going to kill people, sending them back to fen7yn4l and h3r01n.  The blood will be on their hands.  Not only do they produce the drugs that kill people, they want people on them even more because 7oh has saved too many people.

Recent studies by HART have shown ZERO DEATHS can be blamed on 7oh alone -by itself with no other substances involved.

Based on recent reports, the claim that no deaths can be attributed to 7-hydroxymitragynine (7-OH) alone is a point of intense debate, with some health organizations reporting fatal cases while advocates argue it is not the sole cause.

Key Findings on 7-OH Safety and Fatalities:

Reported Deaths:

As of late 2025, the Los Angeles County Department of Public Health linked six fatal overdoses to the synthetic kratom compound 7-OH, noting that victims were otherwise healthy.

“CONTRADICTORY CLAIMS\*\*

Some, such as the Holistic Alternative Recovery Trust (HART), claim there are "zero deaths linked exclusively to 7-OH" in their data, contrasting it with raw kratom leaf.  

LINK TO HART STUDY

HART WEBSITE

WASHINGTON, D.C. – The Holistic Alternative Recovery Trust (HART) today released the following statement in response to misleading and incomplete media reports surrounding a 7-hydroxymitragynine (7-OH): 

“The misinformation circulating about 7-OH misrepresents both the science and the safety record of this compound,” Jeff Smith, PhD, National Policy Director for HART. “The only clinical study cited by the FDA comes from a researcher funded by the Global Kratom Coalition, a group actively fighting 7-OH products that have cut into their market share.

 That unreviewed, unpublished study sought to demonstrate harm by injecting 7-OH directly into mice’s bloodstream, even though humans consume it orally. Anything can be harmful if injected, eat a chocolate bar and you’re fine; inject it and you’ll die.\*\*

 The study was biased and misleading.”

MYTH: 7-OH, not Kratom, is the problem.

FACT:

According to the Food and Drug Administration’s (FDA) own Adverse Event Reporting System (FAERS), there have been under 40 adverse events, and ZERO deaths linked exclusively to 7-OH, despite well over a billion doses consumed nationwide.  

Contrast that with raw kratom leaf, which the FDA itself has associated with nearly 200 confirmed deaths

Polysubstance Misconception: While many cases involved mixtures (particularly with ETOH), health officials \\\*STILL emphasize that 7-OH, acting as a potent opioid, can independently cause fatal respiratory depression.  WRONG

And, another thing I want to throw in there. Read "How to Lie with Statistics by Darrell Huff”

And I will leave you with this-

We should BAN HARD AlC0H0L. It is many times more potent than beer, and taking shots of it increases your intoxication 10x faster than a beer, and raises your tolerance.  2 SHOTS AND YOU ARE OVER THE LEGAL LIMIT AND CAN CAUSE A CRASH.

Ban hard AlC0H0L and keep beer legal! 2 shots and you are at risk of a DUI killing others. Same with 2 beers (although it's harder to drink 2 beers than 2 shots..) Restaurants don't care if they serve you more than 2 drinks, they encourage it since they make more money.  They don't care if you're driving home.  They send people home over the legal limit every day.

  AlC0H0L and b33r both kill hundreds of thousands of Americans every year and that's not count the children and families killed in car crashes.  I read a story almost every day about intoxicated drivers killing kids and families.

1 ALC0H0L related drunk driving death every 39 minutes.

FROM THE CDC

In 2022, 13,524 people died in the US in crashes involving alcohol-impaired drivers, averaging 1 death every 39 minutes. These preventable incidents account for roughly 32% of all traffic-related deaths, highlighting a severe, ongoing public safety crisis.

I’ve worked as a paramedic for over 10 years and not once did I have a call for kratom or 7oh.  Thousands of calls for AlC0H0L, F3N7YN4l, H3R01N etc.  So much trauma, so much pain, so much loss, carnage, blood, dead families and kids from intoxicated drivers.  So much tragedy.

Thank you.