Huge improvement - PDH dysfunction and thiamine (B1) TTFD

I've had a lingering symptom following my second covid infection in 2022.

Every time I consumed carbs or sugar, I experienced brain fog, pain in my veins and a feeling of having lactic acid in my muscles. If I went on a keto diet, all of this disappeared. After over a year on keto, my A1C was still 6.0. I did NOT get this reaction when consuming honey. Used CGMs for months, only to figure out that my baseline was really high (110-120 mg/Dl, still on keto)

I bought this up with over 20 doctors (various specialists) at one of the world's best institutions (Stanford) and ALL of them pretty much just shrugged it off. Saying it's normal, genetics and all sorts of other BS.

Putting all these details into Claude basically identified "PDH dysfunction" as the culprit.

From Claude:
Pyruvate dehydrogenase (PDH) is the gateway enzyme that converts glucose into usable cellular energy. When it's not working properly, glucose gets stuck as pyruvate and can't enter the Krebs cycle to produce ATP—so your cells are essentially starving for energy even though your blood is full of glucose. Since thiamine is a critical cofactor for PDH to function, depleted thiamine stores directly shut down this gateway, explaining why your brain fogs after carbs, your muscles can't get energy, and your nervous system struggles to regulate itself.

This kind of lined up perfectly what I felt.

100mg of Thiamine (B1) TTFD - pain in my veins disappeared immediately.

200mg - started lifting brain fog. Feeling of lactic acid gone.

600mg - I have now experienced a 50% improvement - by far the biggest one I have seen (and I have tried way over 150 interventions at this point).

For whatever it's worth - I hope this can help someone else. Fight on out there. You can do it!