What do you imagine different effects in the spire feel like?

Some effects are pretty straightforward, we can all imagine the types of damage most of the attacks do and what different debuffs feel like or represent, but for example how do you picture the Darkness Orbs doing damage? What is happening to the enemy that takes that hit? Or, what does it feel like to have Doom stacked on you, y’know? Can an enemy sense it building? Is it just a sense of certain doom that builds until it breaks, does it desiccate the enemy like the animation implies, or what? Do any potions strike you as probably being especially yummy or nasty? These are the sorts of things I think about playing this game.