Tips and Tricks i've learned so far.

I personally take bomb dice over everything, being able to bounce more combos, especially late game when you have alot of dice is huge. Even if i'm going a certain build (Archer with the two volley relics is maybe the only one id go volley dice over bomb.) I still take bomb dice over my build.

I used to look for paths with mini bosses for the double rewards and relics, however, now I look for the jesters, if you have one gravity rune or are good with a shockwave rune or a trigger rune, it's way more worth it as you get heals, money, upgrades, and two chests per jester if done right.

Some relics are good, but most aren't better than taking more dice. However the one relic you should always get if you have the chance is the one that heals you 1hp per class dice used. Great for late game.

Early game just try to get the easy 1,2,3,4 combos, but late game figuring out which dice you can bounce into each other to make great combos is key.