Back with a few more questions about syndicate

https://preview.redd.it/gx1kim2w203h1.png?width=2234&format=png&auto=webp&s=bd2ab8cbaaf97a475dadba482c59eb6f9436da54

After my previous post I took a break to read a bit more about how betrayal works. I didn't realize that you need trust links before you can create rivalries, so I've started doing that. My questions are as follows:

1. Is this ok to start ITF foulborn MB farming?

2. Is there anything that will stop me from getting more ITF relationships, both trust and rival links?

3. I've heard that it's ok to run the safehouses of transport and intervention, and that it won't brick. I just need someone to back this up.

4. Why can we not run any of the leaders in the size 5 houses?