Endometriosis + Failed Euploid Transfers: What FET Protocol Finally Worked for You?

Hi All,

Posting on behalf of a friend who is feeling pretty defeated and looking for ideas to discuss with her RE. She doesn’t have a Reddit account and this sub has been so helpful for me when I was going through my IVF.

She has confirmed endometriosis (and adenomyosis), has transferred multiple euploid embryos, and has had several failed transfers, including one chemical pregnancy. Before her most recent transfer, she completed a course of Lupron Depot, but unfortunately that transfer was also unsuccessful.

For those with endometriosis or adenomyosis and eventually had success:
- What was your FET protocol?
- Did you do Lupron Depot? If so, for how long?
- Did you have surgery before transfer?
- Did you use letrozole, antihistamines, steroids, intralipids, or any immune treatments?
- Was your transfer fully medicated, modified natural, or natural?
- How many transfers did it take before you found the protocol that worked?

Would especially love to hear from anyone who had multiple failed euploid transfers before finding success. What ended up being the missing piece?

My suggestion was for her to get a second opinion, but I wanted to help gather real-world experiences and ideas she can discuss with her doctor before deciding whether to move on from her current clinic.

Thank you all in advance ❤️ We truly appreciate any insight you can share.