Leukemia treatment in Minneapolis

My friend did her original treatment in AZ, but lives in MN in the summers, and also has her 95 year old failing health mother a few blocks away from her up there. Now that the Ponatinib is failing, will they just jump right into a SCT? Won’t they try another TKI, or more rounds of Blino? And can she do all this up in Minneapolis? Is there a good hospital up there? I’ve read good things about Mayo, but that’s in Rochester, and over 2 hours away. I’ve heard the conditioning phase of SCT can kill you, and there are no guarantees that it will even work, and at 63, is it even worth the risk?