Sinisister status effects kinda missed potential

I just got done playing sinisister 2 and while I love the game I was a little disappointed that a lot of the status effects don't really do much than change mp or are exclusive to an ending. Like come on missed chance for zombification to make her pale and red eyed gradually there are 3 levels of the curse or cursed seed give make you hallucinate like in the boss fight where you get it. Got me thinking are there any others games like sinisister that do that better? I've played Night of revenge and that had some good ones too but many do the same. Would be cool if there are games where they can change gameplay and maybe do something like unlock abilities you wouldn't have with downsides. Imagine making a lactation build that lets you self heal but enemies can latch on and take if for them self or the zombie curse makes you zombie walk but makes you immune to certain other effects like sleeping gas or blood suck. I know this is a pipe dream and I would probably be hell on a development team but hey a man can dream. Does anyone else have any cool ideas you would like to see?