Has anyone here taken Duloxetine before?

Side effects

I’ve been on it for a little over 6 months now. During the first week, I experienced vomiting, which I expected as my body adjusted, but the nausea has never really gone away. I constantly feel sick, exhausted, emotionally numb, and sometimes deal with mood swings. On the positive side, it has helped my panic attacks and anxiety significantly, and I’ve noticed a major improvement in that area.

The frustrating part is that whenever I tell my doctors how sick I feel, it doesn’t seem like anyone is really listening. I’ve even ended up in the ER twice because of how bad I’ve felt. I’ve told my doctor that I’d like to start tapering off Duloxetine because of the persistent nausea, but I’m feeling unsure about what to do next.

Has anyone else experienced ongoing nausea or other side effects while taking Duloxetine? If so, did they ever improve, or did you end up switching medications? I’ve tried to tough it out for as long as possible because my anxiety is severe, and I also have ADHD, but I’m starting to wonder if it’s time to consider something else.

I’d really appreciate hearing about other people’s experiences.

Posted Jun 11, 2026, 2:31 AM UTC

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