Cannabis induced anhedonia
I live with anhedonia since summer 2014 and the only thing to fix it is the thing that caused it.
When I am stoned/high I feel like my mesolimbic reward circuitry is back online.
Unfortunately that comes with negative side effects like introspection and anxiety (probably caused by increased introspection). I also feel extremely dumb, it feels like everything is zoomed in and I can’t see the bigger picture, if it makes sense.
One puff is enough to reach this state for the whole day.
What can I do to replicate the effects on my reward circuits without triggering the other effects?
Is PPAR alpha or gamma agonism a good option?
I tried Palmitoylethanolamide and I maybe had a placebo reaction, so could not reproduce it.
Are there OTC nutraceuticals to try or any RCs which specifically help when anhedonia is induced by weed?
Posted Jun 11, 2026, 9:27 PM UTC