Cannabis induced anhedonia

Discussion

I live with anhedonia since summer 2014 and the only thing to fix it is the thing that caused it.

When I am stoned/high I feel like my mesolimbic reward circuitry is back online.

Unfortunately that comes with negative side effects like introspection and anxiety (probably caused by increased introspection). I also feel extremely dumb, it feels like everything is zoomed in and I can’t see the bigger picture, if it makes sense.

One puff is enough to reach this state for the whole day.

What can I do to replicate the effects on my reward circuits without triggering the other effects?

Is PPAR alpha or gamma agonism a good option?

I tried Palmitoylethanolamide and I maybe had a placebo reaction, so could not reproduce it.

Are there OTC nutraceuticals to try or any RCs which specifically help when anhedonia is induced by weed?

Posted Jun 11, 2026, 9:27 PM UTC

2019
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