Systemic Theory

I have a theory that systemic issues following Hyaluronidase come from injection of the enzyme into the blood vein. This destroys the HA in the vein walls, which (I hypothesize) does not naturally replenish like in the skin. The result: hyper-permeable veins leaking fluid into the surrounding tissue.

For those who have had systemic issues: did the provider use needle or a cannula?