165,000 miles on a 5vzfe (3.4l V6) toyota tacoma 2004,  supercharged around 100K by PO. 

Not long after i bought the truck the knock senors failed, putting the truck into a limp mode. I just did those, along with a host of other mostly preventive maintenance parts with mostly oem toyota parts with hopes to daily this another 2-300k. Up to this point I've driven it like I stole it. 

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After this work, and a day of hard driving to see if how it would hold up, I noticed the power was less than before. Next a hesitation or miss developed. A compression test shows 200 psi cold on all cylinders but one at 150. 

The other cylinder next to it took an excessive amount of cranking to reach around 190psi. 

I am playing with a leak down kit but having trouble being confident I'm using it correctly, seems any escaping pressure is going out the tail pipe. No oil or bubbles in coolant, engine oil is clean. 

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I'm trying to decide what to do. I have the space and (some) desire to learn how to rebuild the engine. I am learly of this because I dont know how much I can resurface the heads while being supercharged, or if I will need oversized pistons?  

It appears to be around 3.5k for a used engine of unknown condition

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What direction would you go? Thanks.

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Help deciding what to do with low compression engine