Interesting item

Blocking CCR5 isn’t entirely free of consequences:

•	West Nile virus (mosquitoes) is the clearest concern. People lacking functional CCR5 appear to be at higher risk of severe or symptomatic West Nile infection, and the same may apply to some other flaviviruses (tick-borne encephalitis has been studied). CCR5 seems to matter for clearing those specific viruses from the central nervous system.  
•	Possible blunting of certain immune/inflammatory responses, which is sometimes a feature rather than a bug — leronlimab is being explored in conditions where dampening inflammation is the goal (long COVID, NASH, GvHD, certain cancers where CCR5 drives an immunosuppressive tumor environment).