Duloxetine good or bad?

I've just started Duloxetine and I'm concerned after reading so many horror stories. I've been on 30mg for just over a week and feel tired, unmotivated and more depressed. I finally decided to try it for depression and pain. I'm also on 45mg Oxycodone, Baclofen, Gabapentin, Indomethacin, Clonidine, Dexamphetamine and 10mg Valium a day.

​

I feel my brain chemistry is stuffed and adding more instead of reducing might have been a better idea?

​

How have others gone on duloxetine? I know about the withdrawals getting off. I'll trial the 30mg for max 3 weeks.

Posted Jun 13, 2026, 11:45 PM UTC

121
Loading comments…