[No spoilers] Can I watch Calamity without watching c1-3?

So I've never been into cr until I heard about c4 and the fact that BLeeM was going to be DMing, and as a diehard D20 fan, I just had to check it out. I'm really loving it so far and I want to get into the other campaigns, but the sheer amount of content is intimidating. I've heard great things about Calamity and I think it'll be right up my alley, but I'm not sure if I'll be able to keep up without watching the main campaigns. I did watch the 1st season of The Legend of Vox Machina on prime so I'm not totally clueless, but other than that, I know basically nothing about c1-3. So yeah, can I watch Calamity without being totally lost, and if I can't, how much of c1-3 should I watch before I can start Calamity?