Experience so far on 50mg

I see a lot of negative experiences with Pristiq shared in this group and it made me nervous about starting this medication. I recently transitioned from 20mg Lexapro and 300/150mg Wellbutrin to 50mg Pristiq and 15mg Buspar twice a day. I was prescribed them for anxiety and depression. I could not tolerate the ear ringing and heat intolerance from the Wellbutrin and the Lexapro seemed to make my triglycerides skyrocket. So after tapering off of the old meds and transitioning to the current ones, I can say my experience has been really positive so far. I have been on the Pristiq/Buspar regimen for less than one month, but I would say that my anxiety is well managed and I have not really experienced any major negative symptoms. I do sweat a lot in the morning after taking the meds, but I do live in Florida so that is kind of part of my baseline experience. I bring a usb powered fan with me to use at work. I am sleeping really well at night, my energy levels through the day are normal and I’ve had about 2 days so far where I would describe myself as feeling happy/content. So I just wanted to out my personal experience out there to encourage people considering trying this medication to give it a go. There are risks for everything and there can always be negative side effects with any medication. But overall my experience has been positive. I just wanted to share.

Posted Jun 15, 2026, 12:55 PM UTC

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