Strattera and Genesight

I’ve been on Strattera for about a month and a half. I started on 40 mg and bumped up to 60 mg after 2 weeks. I’ve felt improvements in emotional regulation but they fade after 2 weeks. I’m thinking it’s time to bump up to 80mg.

however, I did a Genesight test months ago and it has Strattera on the red list for 3 reasons:

1: Serum level may be too high, lower doses may be required.

5: CYP2D6 genotype indicates that this patient may experience increased frequency of side effects, but also greater symptom improvement in those who find the treatment tolerable. (I am a poor metabolizer of CYP2D6).

8: FDA label identifies a potential gene-drug interaction for this medication.

Since 80 mg is the therapeutic dose, I figured I’d be ok at 60 mg. I have heard people saying to take these tests with a grain of salt, but I do find some info on it has been accurate.

If I bump up to 80 mg, how can I tell if the dose is too high?