My bun keep growling and biting

I have a female bunny who I keep with her (neutered) brother but as of late she won’t let anyone touch her to the point where it’s a struggle to get her out of their cage(normally they stay there only during the night or when no one is home) to their enclosure where they would normally spend most of their time. And when we do manage to take her outside getting her back inside is also a struggle as she nips her brother if we try to take her.

She also has quite long fur but with her attitude it becomes complicated to brush her without risking getting bitten.

I was wondering what can I do about it ? I also apologise for the bad English