Lifelong PE resolved. No SSRI
Mid-thirties lifelong PE sufferer.
Went on a bit of health kick and found as a totally unexpected consequence, my PE had entirely resolved.
For reasons that aren't relevant, I had to stop this and my PE returned.
I've since been trying to work out which elements were having the most impact and I think I've narrowed it down to a small combination of things. YMMV:
I've been taking daily:
Tadalafil
L-citrulline
Na-R-ALA
NAC
Magnesium glycinate
Exercise - Spinning, Squats, Pushups
After a solid couple of months of this, with a once weekly spinning class and some basic daily exercises like squats and push-ups, I'm back to this resolved state.
Extensive googling and research has revealed the The NO/eNOS/cGMP pathways which lead to smooth muscle relaxation and this seems to have really helped.
It's been transformative for me and wanted to share with you all!
Posted Jun 25, 2026, 7:03 AM UTC