Late sensitization to LDN?

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Hey there, I need some advice! As background I have very severe ME/CFS ( mostly bed bound ) and I'm super sensitive to all stimuli, so I was aware of potentially being very sensitive to LDN too. So I started with 0.1 mg and increased by 0.1 mg every 1-2 weeks. With each Increase I would get slight headaches and Insomnia for 2-3 days, which then improved. Months later when I was at 1.75 mg I increased too fast in one week to 2 mg. I had the same headaches and insomnia, only stronger, but they persisted and after a week my whole condition deteriorated on various parameters. I couldn't connect it to the LDN right away and when I realized it, it had already accumulated to some degree in my body. I decreased the dose and after a week or so my condition improved back to normal. So I stayed on that dose and was fine. Until a couple weeks later on that same dose the same side effects appeared again didn't go away. I decreased the dose again and even paused LDN for a couple days completely, which helped, and started back with a much lower dose. I decreased more and more but I don't find significant relief from the side effects. So now I am at only 0.35 mg every other day and still have side effects.

Was this a sensitization process? Does anyone here have experience with this? What to do now?

Thanksss in advance!

Posted Jun 27, 2026, 10:38 AM UTC

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