HGST Ultrastar, Seagate Barracuda & WD Greens. Total around 80tb . Safe to run in Raid5 in OWC Thunderbay 4?

I recently bought some old drives, most of them at 15,000 to 30,000 power on hours.

I’ve got 17 HGST Ultrastar, Seagate Barracuda and WD Greens with a total of around 80tb.

Perfect smart data, no cautions or anything.

Should I use Raid5 for multiple of these or is there a much higher risk? I know they’re CMR drives so it should be fine.

Would it be wise to use these in my OWC Thunderbay 4 with Softraid / RAID5?

Or is there a significant risk because the drives have a lot of power on hours?

Thanks!