Fisetin is strong in mice - but human senolytic data is still not published

Been deep in fisetin sourcing. It's a genuinely exciting senolytic in animal studies (a 2025 mouse study put it on par with potent senolytics for frailty/grip strength). But as far as I can find, there's still no published human data on its senolytic effect - trials are ongoing (osteoarthritis, sepsis). Add low bioavailability and fast metabolism. And one sourcing thing worth knowing: "98% by HPLC" depends on the method - the same material can read 98% on a short ~20-min run but ~85% on a proper ~30-min run that resolves co-eluting impurities, and a lot of COAs don't disclose the method at all. So practical takeaways: ask for the HPLC method + reference standard (not just the number), decide daily vs the intermittent "hit-and-run" dose on purpose, and look for a COA. Not anti-fisetin at all - just pro-honesty.

(Disclosure: I work with an ingredient supplier, NaturalBestBio; flagging bias, not linking anything.)