Recruiter here; to my fellow Recruiters, have you successfully navigated agency-side & in-house roles in multiple industries?

For those of you who have successfully navigated both inhouse and agency recruitment, how do you find shifting focuses in different industries? I have been in a niche industry for the last 10+ years in agency and inhouse roles, and part of me is considering to (1) step into a dual recruiting/professional development role or (2) try a completely new industry.

Has anyone successfully navigated a new industry? Did you have any challenges or regrets?