Mass photometry is amazing!

So we hypothesized that our protein was a decamer (10-mer) based on literature review. We sent our protein out for mass photometry analysis and got a unimodal histogram of the masses of the particles in solution showing that it is a decamer. We sent our protein out for cryoEM data collection. The cryoEM maps show that it is a ring decamer.

Mass photometry was invented in 2018 and it detects the mass of particles in solution using light scattering.

I ❤️ mass photometry!