Starting a Deadlands campaign!

Heya gang, after 3ish years of running my Midnight Crew pulp campaign (using SWADE), my players and I both got the itch for something new- and SWADE Deadlands fit the bill! I’m not super familiar with the setting but I love what I’ve read so far.

I plan on having the party start in El Paso, as they’ve all, for whatever reason they so choose, have taken work from an advertisement in ‘The Epitaph’- to safeguard a Doctor* of unusual ability in his travels to the Sioux Nation. I worked to make a Traveller style background generator for my players who are into that sort of thing, and it’s gone great so far!

The only info the Deadlands SWADE book has on El Paso is that it’s the seat of a squabble between Bayou Vermilion and Lone Star Rail (voodoo zombies vs post-confederate militants?), but given how close it is to the border with Mexico, that could be a source of drama too.

Do you cool cats have any thoughts as to what neat weird west stuff I could inflict upon my party? I planned on doing a Tremors type scenario, but I’ve got to sit down and chew it out first. Could Lone Star be trying to pass the blame for something onto Bayou Vermillion? Could the control over the voodoo zombies be tenuous, and broken by an outside force?

*a previous player character from an earlier Weird West game, Doctor Irvin Wolfe has a set of surgical equipment made of an unearthly metal, which, besides increasing the skill of the good doctor enormously, also will allow him to ignore the anti-technological field of the Sioux Nation; this has made him a target, of foes both earthly and otherwise, have the want for particularly skilled protection.