UTI-Like Symptoms during Doxy

My Experience

I had to share this, in case anyone else is going through it as well. I just started my 14 day doxy journey on Monday. The first evening, I started getting urgency, tingly sensations in my urethra and was sure I was developing a co infection. This proceeded into the next day as I continued my treatment. I'm on day 3 now and it feels a lot better. I've read on here that this can happen when the ureaplasma leaves the body. Anyone else have these side effects/symptom flares on Doxy?

Hx: 35F. No prior history of recurrent or chronic UTIs. New partner in 2025, 4 E. coli UTIs over a 6-month period after we stopped condom use. Continued intermittent urethral irritation/tingling between infections and tested positive for Ureaplasma urealyticum. My partner and I have both started 14 day 100mg BID doxycycline treatment on July 6, 2026 and plan to take azithromycin for 4 days after we finish.

Posted Jul 8, 2026, 12:04 PM UTC

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