This video features a deep dive conversation with Denis Noble, a pioneering physiologist known for building the first computer model of the human heart in 1960. Throughout the episode, Noble challenges the gene-centric "selfish gene" view of biology, arguing that life is better understood through a systems biology perspective where agency exists at multiple levels.

Key Discussion Points:

•	Critique of the Modern Synthesis: Noble argues that the central dogma of molecular biology—that genes are the master regulators—is incomplete (0:04:43). He emphasizes that it is the organism and its systems that determine how genes are used.  
•	Cellular Agency: Noble describes how individual cells, such as those in the immune system or cells studied by Michael Levin, display agency by acting with purpose outside of their normal context (0:48:09).  
•	Lamarckian Inheritance: He discusses the return of "Lamarckian" views, citing evidence that acquired traits or epigenetic changes can be inherited through extracellular vesicles that carry information to the germline (0:22:53, 0:29:40).  
•	Challenging Biological Myths: Noble clarifies that the classic example of the peppered moth (industrial melanism) was not a result of slow natural selection via point mutations, but rather a rapid change driven by mobile genetic elements (0:17:30, 0:42:03).  
•	Purpose in Biology: He illustrates how teleological or "purposive" explanations, such as those used by William Harvey to predict blood capillaries, remain a powerful tool for biological discovery and system modeling (0:55:05).  
•	DNA Fidelity: Noble highlights the extraordinary mechanism by which cells orchestrate over 800,000 error corrections during DNA replication before division, demonstrating that life actively maintains order against chaos (1:04:20).  
•	Consciousness as a Process: Reflecting on the nature of consciousness, Noble argues that it should not be viewed as an object, but as a dynamic process of being "sensitive" or "conscious of" something via sensory connections (1:27:31).

Denis Noble: Neo-Darwinism, Michael Levin & Why The Last 70 Years of Genetics Is Wrong