Lexapro worked great for anxiety, but Trintellix isn’t. Increase dose or switch back?

So I was on 10mg Lexapro for about a year and it worked amazingly for getting my anxiety under control. I honestly love this medication. However, I decided to switch to 10mg Trintellix (vortioxetine) about 3 months ago. I made the switch because Lexapro did cause some annoying side effects (libido and the other stuff etc etc).

Anyway, I feel like Trintellix is doing very little for me. My anxiety and constant worrying have come back full force. It’s gotten to the point where I’m starting to feel low, which is strange because I’ve never really struggled with low mood before, only anxiety..

My doctor has given me two options:

  1. Go back on Lexapro and introduce Wellbutrin to try to reduce the side effects I had, so a combo.

  2. Increase Trintellix to 15mg (has anyone found this helped in a similar situation?)

Has introducing Wellbutrin (bupropion) helped anyone combat side effects? Did it have an impact on sleep? Would love to hear from anyone who has been in a similar situation or tried either option. Thanks so much 😊

Posted Jul 9, 2026, 7:57 PM UTC

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