Is there a situation where a guy taking a long time to respond isn’t a sign of disinterest?

I’m back to dating, mostly starting online (Bumble, Feeld, etc). Some guys are pretty regular message responders (multiple times a day, daily). Other guys will take over a day to respond, even when I’m asking questions (ie not just a natural die down of the conversation).

For the guys that take over a day to respond to a question, that means they aren’t interested right? Like I understand being busy during the work day or having other stuff occupy your time. But over a day or even over multiple days must be a sign that they aren’t invested/ aren’t interested, right?