First effects/feeling weird after first dose

I just received my first vial of estradiol enanthenate, I haven't dosed myself yet though cause I've done research and apparently after first dose it is common to feel sick or have headaches and things. How common is this really though? I have rly bad anxiety n worry about like if it's laced or like all that stupid illogical stuff and just need some re assurance and honesty. How common is it to feel weird after the first dose and how bad can it get?

I feel a bit strange and have a headache n feel sick today so I'm waiting for another day where I feel kind of better for the first dose in case it makes me feel bad or sick. I also don't rly wanna wait either cuz obv I'm super excited n pretty happy I'm just a tweaker and feel scared.