Crashing to Desktop after Few Seconds of Play-Time

In my most recent city I have started to encounter crashes that occur within about thirty seconds to a minute of starting the save (with the simulation playing). The crashes occur spontaneously: no frame drop, the game is responsive up until the crash, no hardware usage spikes (although it averages somewhat high, memory 81%, CPU 50-75%, GPU 70-80%).

I have tried setting the graphics to very low, this had no change on whether the crash would occur or not. Simulation speed had no effect either.

I do not have an Intel CPU (I am using an AMD 5600X and RTX 3060) which I found out to be the cause of a similar issue, https://forum.paradoxplaza.com/forum/threads/i-fixed-my-random-crashing-to-desktop.1727434/ .

My city's population is 455,000. I am using a few mods, Articulated Buses, Write Everywhere, and a few station and vehicle asset mods. However, I doubt these types of mods would impact the stability of the game significantly?

I have encountered random crashes like this in the past in smaller cities with absolutely no mods, but nowhere near this level of frequency.

Any help would be greatly appreciated. Is there any data I can collect that would help find the cause? Is it possible that my playstyle or certain unlockable buildings contribute to this?