Plz help in stopping side effect of L-methyl folate
Hi,
TLDR: Had symptoms like anxiety and insomnia for 2 years. After taking L-methyl folate 1mg/day for few weeks, symptoms disappeared but two side effects started - 1) dizziness when body and head moves/turns many times in a day due to day to day activities and 2) inability to think deeply. Stopped it and started niacin 30 mg/day for 3 weeks. Deep thinking came back but dizziness has continued. What should I do? BP and b12 are normal. No other disease.
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Details:
About me - I am MTFHR A1298C variant. COMT is normal. Due to some personal tragedies, I have been experiencing anxiety and insomnia for 2 years. I have taken b complex supplements in past. My b12 and BP are normal. I don’t have any other health problems and dont take any medicine, except supplements like melatonin/magnesium/ashwagandha for insomnia. Age.- middle age, Male gender.
To solve these chronic symptoms of anxiety and insomnia, I took L-methyl folate for few weeks:
- First 2-3 weeks - L-methyl folate 1 mg/day. -> Anxiety and insomnia both solved!! - AMAZING
- Next 2-3 weeks - Two side effects started - 1) dizziness when body and head moves/turns many times in a day due to day to day activities and 2) inability to think deeply. No other side effect. So reduced dose to 100 mcg/day. Symptoms continued. Dizziness stops temporarily upon resting.
- Next 3 weeks - Stopped L-methyl folate completely. Started NIACIN 30 mg/day. Deep thinking came back. But dizziness reduced only by 30%.
What should I do to solve the Orthostatic dizziness? There is no functional medicine expert in my country to consult. Plz help.
Chatgpt/Gemini suggested to try following:
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Hydroxycobalamin or NAC or curcumin (first option preferred) to absorb Nitric Oxide (which might be the culprit of this symptom)
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Potassium supplement was an initial recommendation but chatgpt ruled it out as there is no other symptom of potassium deficiency like muscle pain, anxiety, jitteriness etc.
Q1 - What should I do. Without any new supplement, will this side effect go away on its own? If yes, in how many weeks. It’s quite difficult living daily life with this side effect.
Q2 - If at all I have to take some supplement to solve this side effect, what sld I choose?
Q3 - As Niacin is not showing any further benefit, I am planning to stop it. Is that ok?
Plz help.
Posted Jul 11, 2026, 2:20 PM UTC