Cirs mcas binder sensitivities help!

What’s everyone doing in order to tolerate csm/welchol… every time I try it I flare up MCAs and can’t seem to tolerate it even at tiny dose! I’m on kpv and ketotofin and still doses not help! Am I doing something wrong? I’d think it could be my gut dysbiosis and am gonna trial low dose VIP peptide! Thoughts? How were you able to tolerate binders with mcas?