ROAD TRIP GAS MILEAGE PREMIUM VS REGULAR

Just thought id see if anyone on here has any experience or insights that would be helpful and any feedback is welcomed. So I am planning on taking a road trip coming up that is roughly 850 miles round trip with 95% of that being on the highway. The vehicle ill be driving is my 2001 Ford Excursion 4x4 with the 6.8 v10. My thought/question is that if i fill up with premium instead of regular will i potentially get more miles out of a single 44 gallon tank than if I used regular and with today's gas prices being what they are would it be worth considering price per mile kind of thing if that makes any sense. I have made this exact trip multiple times before on regular gas and can do a round trip for about $300 using about 7/8 of a tank there and another 7/8 on the return trip. I have noticed a difference in milage between decent and low quality gas and had the thought that premium may or may not make that much more of a difference.