What to expect on the first few days of semaglutide?

Hello! I just started compounded semaglutide with B12 on Monday. I started on the 0.25 dose.

I'm wondering what one should expect for the first week or so of being on these meds and this dose. So far, I haven't felt much at all. Some mild bloating Monday, and I \*feel\* like I'm getting fuller faster, but that could be in my head. I haven't experienced any adverse side effects luckily.

Does this sound about right for someone who's only a couple of days in? I'm only worried because my medicine arrived lukewarm. The ice in the packaging was still sweaty, and the liquid was completely clear when I drew it out for my injection, so I went ahead and took it based on what I had read online, but I'm mildly worried that this vial is a dud.

Thank you in advance for any insight you can give!

Posted Jul 30, 2026, 2:02 PM UTC

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