Everyone hostile or fleeing?

For whatever reason, all of my companions are in hostile or cautious mode, whatever it is where their weapons are drawn like an enemy is nearby. NPCs virtually all flee like someone's been killed or an attack is going on. I don't know what the reason for this is. All my reputations are good or neutral. It's making advancing any mission virtually impossible because all the characters flee, and it breaks conversations and quests.

Any advice?