Di2, fully wired or not ?

I am waiting for my frame that is somewhere between China and Europe. Now, I want to install a Di2 groupset. Is there any reason to NOT run it fully wired ?

From what I can read, it seems the battery will run 50% longer, and it turns off the 24/7 listening BLE radio. Cost is 2 extra cables and a JC304. And there will be no wakeup time. And then I can wirelessly upgrade the shifters, and remove the CR1632 batteries.

So only upside apart from having to route 2 short cables to a junction box at top of downtube, and a longer cable down to the battery. Isn't there any disadvantages ? apart from the 10g and a little extra installation work ?