It’s crazy to me how drastically different dosages affect different people

Been on Reta for 6 months now (even typing that seems crazy to me).

I started at 2.5 mg per week, then increased to 5 mg where I stayed for around 4 months. I’m now sitting at 7 mg and will see how I go from here.

My weight loss has been “OK” during that time. I’ve lost around 22 lb, but I’ve currently been stalled for about 4 weeks, which is why I’ve started titrating up again.

One thing I find really interesting is how different everyone’s response seems to be. I see people on here starting at 0.5–1 mg per week and getting amazing results, while other people are working their way up towards 10 mg.

I’m over 300 lb, and sometimes it feels like 5 mg barely made a difference anymore after being on that dose for so long.

I know this is going to be a long journey for me, but I’m OK with that if it works over time. I’ve got around 2 years’ supply stored, so I’m trying to be patient and find what works for my body.

It just fascinates me how some people seem to respond strongly to tiny doses, while others need much higher doses. I’m curious what’s actually happening biologically that makes one person respond to 0.5–1 mg while another person needs much more to get a noticeable effect.

Anyone else experienced this big difference in dose response?