Which supplements actually reduce epigenetic age in humans?

A systematic review analyzed 41 human intervention studies, including trials on omega-3, vitamin D, multivitamins, NAD+ precursors, polyphenols, and other popular longevity supplements.

The results were mixed. Some supplements produced repeated signals across next-generation epigenetic clocks, while others failed to deliver convincing effects despite strong biological theories and considerable hype.

The analysis also explains why improving a single clock result does not necessarily mean that the body has been genuinely “rejuvenated.”

🔗 Full analysis