Any tips for managing Lyrica fatigue?

Advice

I finally have some relief from the back and hip pain that has been plaguing me for three years. It’s amazing. I have either undifferentiated connective tissue disease, suspected psoriatic arthritis. Before Lyrica, I tried strong NSAIDs, prednisone, cortisone shots, Tylenol, PT, massage, prescribed opioids from Pain Management, muscle relaxers, topicals, DMARDS, a biologic, which helped with other symptoms. But nothing touched the back and SI area pain until now with the lyrica.

I can finally move without unmanageable pain, it’s so great! But the fatigue and heaviness is making me feel almost like I’m depressed.

I take it before bed and first thing in the morning, not a huge dose, but I’m left feeling tired and depressed until about noon.

Any tips? Recommendations? Things I can ask my rheumatologist or primary care doctor for to make this more manageable?

Posted Aug 8, 2026, 5:26 PM UTC

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