How different is Patho2 from Classic HD?

It might sound like a dumb question, but hear me out.

I'm finishing up my Haruspex run in Classic HD. I finished the Bachelor's about a week and a half ago. I've been playing this game obsessively for about a month. No regrets... But I am burning out a little...

I expect I'll probably finish this run over the weekend. I'm just wondering if I should take a break for a short while afterwards, or if Patho2 is different enough for me to be able to switch to it and then come back later for Clara's story.

Would appreciate any advice :)