Side effects of . 01 estadiol cream and other treatment options

# I started the . 01 estadiol cream a week ago. I am having extreme tiredness, I mean extreme.. completely wiped out and depressed mood with this that is drastically different from before I started using this. I am post menopausal and am having atrophy symptoms with extreme suddenly dry, hair, skin, nails... Everything is dried up. I don't know what my next steps should be I should also note that I have severe hot flashes to where I throw off all of my clothes after a millisecond of these extreme temperature changes. I go through this 20 times a day. There is no sleeping. The vaginal atrophy has been going on for 6-7 years and these horrid hot flashes for about 1 1/2 years now. It's like pulling teeth to get my Doctor to do anything about it. Any advice will be so very appreciated.