Do you guys find yourself tweaking pedal settings every time?

Not sure if I am just playing differently each time, or if my ear hears it differently...but every day I end up tweaking my pedal knobs slightly. I just got back from a week of vacation without playing and my pedals sound like crap to my ear now which is crazy because it's the same settings I've had them on.

Specifically what's annoying me right now is SD-1 into BD-2. I feel like the SD-1 is way too "mid humped". I like the distortion but I feel like there is ZERO bass at all when I have the SD-1 on. Last week I thought the settings were perfect but last night I almost wanted to get rid of the pedal.