Any experiences with Parnate producing social anxiety?

:Parnate: Parnate (Tranylcypromine) :Parnate:

I’ve been on Parnate for over 4 months, moved from 30 to 40 and now 50mg. It’s the first psych med I’ve ever tried that is giving me relief for TRD, SI and GAD. In combination with Li and weekly ketamine treatments which will end soon.

I know Parnate is actually used to treat social anxiety issues.

Wondering if there’s any experienced with increased social anxiety? Sleep has been slammed, and I’ve had to stop taking Vyvanse from paradoxical hypertension. Other than that the most noticeable thing I’ve found is that I’ve become very disinterested and uncomfortable in engaging with friends, family, coworkers and even strangers. I’m finding myself going out of my way to not engage with people which is pretty counter to my personality, and counter to Parnate expectations.

Posted Aug 12, 2026, 2:00 PM UTC

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