Having problems with Crushers, bring fire.

The creamator and hotdog are the two I would recomend the most. as both level everything in the sub faction. That said the main reason I recomend fire is it stops their health regeneration.

Bring fire to stop the giants from regenerating their health and flame streams allow allies to more easily hit and kill the things. works really well when they mass up on higher settings. which is why I say the creamator or hot dog.

do not use the primary, secondary, or light support flamethrowers. as they don't have the range to deal with them with out you getting bonked.

That said the shorter range flamethrowers are really really good at clearing out the necromorphs.

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the new sub faction is also hard countered by a guy in a lumberer of all things. which normally I would only recommend taking vs the bugs.

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If you don't want to use fire, gas also is good at slowing them down, while it doesn't knock out their regeneration like fire does it slows them down enough to hit them with heavier weapons. just not as viable in higher difficulties.