What explains crashes, even years later?

What explains this issue? Where someone even one who has improved or remitted years later suddenly takes some normally benign supplement, drinks or something and then has a crash in anhedonia and other symptoms?

It happens even in the akathisia communities where recovered people can get retriggered into the nightmare in a flash.

To me this aspect does not seem like a metabolite thing. It seems like a legit neuroplastic or epigenetic memory being retriggered. Almost like a “PTSD” except its not a regular psychological PTSD its a “chemical PTSD” at the cellular level and is often extremely refractory to standard PTSD methods like EMDR.

Also the more one crashes the more sensitive they get to things too. I know of people who crash from even just smelling chemical scents, and its affected me too.

The ANS has gone completely haywire and there does not appear to be some sort of easy reset and deletion of the cellular memory. The so called “brain retraining” programs do not work because of the unique nature of the symptom presentation being anhedonic, and joy and connection is necessary for safety signaling. Something needs to be designed physiologically to restore safety in the nervous system.