Has anyone had MCAS that was “caused by”/worsened by SIBO/IMO and got better after treating that?
I have POTS and suspect I have comorbid slow stomach motility that has caused me to have methane SIBO/IMO. When I found out about MCAS, it was because of all the stomach issues that I’ve developed since getting POTS, but it’s also symptoms I recognize having to a smaller degree even before that.
I’ve now learned more about how SIBO can hinder the breakdown of histamine, so I was wondering if there’s a possibility that getting the SIBO treated could help also get me back to the low level MCAS-like symptoms I had before all of this started.
To add, the reason I suspect something like MCAS and not just histamine intolerance caused by SIBO is reactions like several times when I’ve taken a walk after dinner, to help digestion, and then slowly started to feel like I’m choking and getting pain in my face and temples. The same chocking I’ve noticed in other situations, where it often comes with a headache and thought I often don’t know what it’s from, other times it’s very obviously after eating, especially after processed foods. And I remember having had attacks of pain around my temples and in my ears when walking late at night even before my POTS/dysautonomia, but it was very seldom.
Posted Aug 19, 2026, 8:09 PM UTC