Homozygous for T allele of C677T - what now?
Hi! I got a psychotropic genetic test recently because I had tried several antidepressants and none of them worked for me. I ended up learning that I am homozygous for t allele of c677t in mthfr gene. After lots of research I’m pretty sure this is where my untreatable lifelong depression and anxiety is coming from (along with facial flushing, itchy/burry eyes, etc). Im sooo sick of being sad, fatigued and anxious all the time but I’m overwhelmed with the information and don’t know where to start!
I feel like it’s cheaper for me to try out some supplements than it is for extra blood and genetic tests (not covered under my insurance until I hit deductible and I’m not even close). Here’s the list of possible supplements but what do you think would help the most?
- B12
- B2
- methylated folate
- TMG
- SAMe
FYI: I currently take Vyvanse for adhd and I’ve been taking Claritin daily for my itchy eyes/facial flushing but it doesn’t really work.
Posted Aug 21, 2026, 2:25 AM UTC